联系人：李先生
2015年8月13日讯/生物谷BIOON/-全球疾病死亡的主要原因是心血管疾病。最近，高血压已经被世卫组织和美国心脏协会认为是常见心血管病危险因素。不幸的是，只有不到45%的患者目前服用降压药物有良好的效果。现在迫切需要找到更有效的药物治疗高血压病人。
“当前美国高血压治疗指南推荐所有高血压患者每天运动30分钟。然而，目前还不清楚到底需要多少锻炼对由于疾病或年龄引起的心脏虚弱的患者来说是既安全又有效的。事实上，不同强度的运动对细胞的影响是未知的。“Deepmala Agarwal博士说是路易斯安那州立大学研究员，他的研究揭示了当高血压患者在锻炼时在细胞水平上发生了什么。
“虽然几十年来锻炼的有益效果众所周知，但长期锻炼对高血压的影响仍不清楚。更重要的是，通过运动发挥作用仍缺乏分子机制。”Agarwal博士说。她致力于研究高血压的相关文章发表在《Hypertension》杂志上。由于其文章具有新颖性和具有较高意义，她的原稿被《Hypertension》杂志选为评论文章。
Agarwal博士和她的同事在路易斯安那州立大学长期致力于人类原发性高血压动物模型的运动研究。研究组首次透露，定期的中等强度运动会延缓高血压的进展。离子在高血压的早期阶段可以******化自己的心脏保护作用。
使用高度复杂的******进的无线电遥测法和分子生物学工具，她能够得出这样的结论：中等强度运动对与高血压相关的炎性过程具有非常有益的影响。“我们还发现，中等运动的有益影响是通过减少促炎细胞因子和氧化应激从而导致心脏内一氧化氮水平的增加实现的。”Agarwal博士说。（生物谷Bioon.com）
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Exercise and Proinflammatory Cytokines Role of Proinflammatory Cytokines and Redox Homeostasis in Exercise-Induced Delayed Progression of Hypertension in Spontaneously Hypertensive Rats
Deepmala Agarwal, Masudul Haque, Srinivas Sriramula, Nithya Mariappan, Romain Pariaut, and Joseph Francis
Hypertension is a well-known risk factor for various cardiovascular diseases. Recently, exercise has been recommended as a part of lifestyle modification for all hypertensive patients. However, the precise mechanisms of exercise training (ExT)–induced effects on the development of hypertension are poorly understood. Therefore, we hypothesized that chronic ExT would delay the progression of hypertension in young spontaneously hypertensive rats (SHRs). In addition, we explored whether the beneficial effects of chronic ExT were mediated by reduced proinflammatory cytokines and improved redox status. We also investigated the involvement of nuclear factor-κB in exercise-induced effects. To test our hypotheses, young normotensive (Wistar-Kyoto) and SHRs were given moderate-intensity ExT for 16 weeks. Blood pressure was determined by the tail-cuff method, and cardiac function was assessed by echocardiography. Myocardial total reactive oxygen species and superoxide production were measured by electron paramagnetic resonance spectroscopy; tumor necrosis factor-α, interleukin-1β, gp91phox, and inducible NO synthase by real-time PCR; and nuclear factor κB activity by electrophoretic mobility shift assay. Chronic ExT in hypertensive rats resulted in significantly reduced blood pressure, reduced concentric hypertrophy, and improved diastolic function. ExT significantly reduced proinflammatory cytokines and inducible NO synthase, attenuated total reactive oxygen species and superoxide production, and increased antioxidants in SHRs. ExT also resulted in increased NO production and decreased nuclear factor κB activity in SHRs. In summary, chronic ExT delays the progression of hypertension and improves cardiac function in young SHRs; these ExT-induced beneficial effects are mediated by reduced proinflammatory cytokines and improved redox homeostasis via downregulation of nuclear factor-κB.
